Minoxidil**
Minoxidil is the first of the drugs approved for hair loss. Introduced
in 1988 after the FDA gave its approval, Rogaine has been an effective
medication for hair loss in both men and women. The topical formulation
is now available in 2% and 5% strengths, and has been over-the-counter
since 1996. The treatment is a hair growth stimulator and works by
activating potassium channels in follicular cells. Numerous clinical
studies have
been done and reported for both hair growth and hair maintenance end
points. This product is only effective in the case of adrogenetic
alopecia, or
male/female pattern hair loss. It would not be effective for hair loss
due to chemotherapy, stress, malnutrition, or alopecia areata.
Finasteride**
Finasteride, or Propecia™/Proscar™*** is the newest medication
to be approved by the FDA for hair loss. Approved in 1997, it is a 5-alpha
reductase blocker and lowers DHT levels, which results in hair maintenance
and may result in hair growth. Clinical studies show, a remarkable 90%
of participants in the experimental group either gain or maintain their
hair approximately five years longer than participants in the placebo
group. While some people see results in as little as 6 months, study’s
show that hair count can increase for up to 18 months. In clinical studies
no one had an increase after 18 months.
** This information was taken from The Hair Transplant Forum International,
May/June 2003, pg229-331
*** Propecia and Proscar are registered trademarks of the Merck Corporation